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The Science Demilitarized Zone (Science DMZ) is a network environment optimized for scientific applications. The Science DMZ model provides a reference set of network design patterns, tuned hosts and protocol stacks dedicated to large data transfers and streamlined security postures that significantly improve data transfer performance, accelerating scientific collaboration and discovery. Over the past decade, many universities and organizations have adopted this model for their research computing. Despite becoming increasingly popular, there is a lack of quantitative studies comparing such a specialized network to conventional production networks regarding network characteristics and data transfer performance. But does a Science DMZ exhibit significantly different behavior than a general-purpose campus network? Does it improve application performance compared a to general-purpose network? Through a two-year-long quantitative network measurement study, we find that a Science DMZ exhibits lower latency, higher throughput, and lower jitter behaviors. We also see several non-intuitive results. For example, a DMZ may take a longer route to external destinations and experience higher latency than the campus network. While the DMZ model benefits researchers, the benefits are not automatic, careful network tuning based on specific use cases is required to realize the full potential of Science DMZs.